Given the uncertainty of outcomes in the biotech industry, consideration of variability is an inherent part of the decision process. Often, the mean (average) is not a relevant decision criteria. This is especially true for smaller biotech companies like Vertex – the opportunity costs are extremely high because scarce capital resources would be invested elsewhere, with a higher probability of realistic return. For example, a company may reject a project which is profitable on average (positive Net Present Value) because some of the possible outcomes are unacceptable to the decision maker. Consideration of variability allows a decision maker to bring in their own risk tolerance into the decision. A similar argument applies when estimating a safety margin above a base case (e.g. in cost budgeting).
Vertex’s strategy and analytics group within the corporate finance division seeks to provide the senior management with dynamic revenue and profit forecasting methodology that helps to identify types of drugs that should be developed given a finite amount of cash and resources. A traditional financial view allows the user to identify scenarios and potential outcomes, but lacks the ability to show the range of potential values within each and every outcome. Vertex’s team uses the DecisonTools Suite to establish the average outcome, the variability of outcomes and to pressure-test risk and uncertainty of a particular scenario throughout the decision process.
Vertex’s team built a complex financial risk analysis model using @RISK to enhance its portfolio process. Monte Carlo simulation and optimization are used to analyze and optimize project and portfolio decisions, given short and long-term corporate strategy. @RISK is also frequently used throughout the business development process: simulating across multiple sales forecasts provides BD team with a range of potential outcomes, making it easy to pinpoint a particular scenario on a curve, along with its probability and value. TopRank turns the sensitivity analysis into a quick and seamless exercise, answering multiple what-if questions within minutes. Franchise and program leaders can now see a dollar effect of their program being delayed or advanced, adding supplementary indications to the development plan and even addressing the price uncertainties all at the same time. The simple interface of PrecisionTree along with tornado chart outputs makes it easy to explain the effect and importance of a particular assumption / decision to an audience with no finance background.
As the company continues to grow, adding more drugs and collaborations to its development pipeline, we will see in this free live webcast how the DecisionsTools Suite remains one of Vertex’s analytical tools of choice to enhance and guide the decision making process.
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Palisade’s Six Sigma Calculator allows you to create a function that models the performance of a process with uncertain elements. It allows you to include uncertainty around design factors through the use of probability distributions. It was built by Palisade Custom Development using the @RISK Developer’s Kit (RDK) to perform a Monte Carlo simulation so the following process capability metrics can be calculated: Cpk, Cpk Upper, Cpk Lower, Sigma Level, DPM, Cp, Ppk, Pp.
I have recently spoken to several clients whom have all came to the same conclusion about the risk analysis solution they think is most appropriate. They don’t want to do it, and I have no problem with that!
In the example he presents, a company is trying to decide how best to balance the sales of certain families of products to maximize revenue, maintain a diverse product line, and properly price each individual product based on the impact to the manufacturing schedule and fixed cost allocation.



Question for today: What do you get when you run Monte Carlo software back in time?
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Just a couple of months ago when gas cost over $4/gallon, Americans were scrambling maximize their fuel economy and buying hybrid electric vehicles to save money, cut our dependency on foreign oil, and to save the earth. At that time, a very wise friend said, “Wait and see, gas prices will come back down and we (Americans) will forget all about it.” What happened over the next few months is exactly as he predicted. If it were not for the domestic automakers being on the brink of economic collapse, there would not have been any recent talk of innovation, reform, or the need for more efficient automobiles. 
Last week, Palisade Corporation held its North American User Conference; it was a very successful event that brought together @RISK Users from around the world. Presentations and discussions touched on topics such as the subprime mortgage crisis, financial risk management, modeling flu, project risk management and of course, the ways to Monte Carlo simulation in Six Sigma.
There's been a real bloom in the number of
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